首都醫(yī)學(xué)科學(xué)創(chuàng)新中心[Chinese Institutes for Medical Research (CIMR), Beijing]（簡(jiǎn)稱(chēng)創(chuàng)新中心）是北京市新成立的具有獨(dú)立法人資格的新型研發(fā)機(jī)構(gòu)。創(chuàng)新中心以推動(dòng)醫(yī)學(xué)科學(xué)發(fā)展、改善人類(lèi)健康為目標(biāo)，開(kāi)展生物醫(yī)學(xué)研究，致力于提升醫(yī)學(xué)科學(xué)創(chuàng)新與成果轉(zhuǎn)化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學(xué)家，與首都醫(yī)學(xué)教育和科學(xué)研究?jī)?yōu)質(zhì)資源緊密合作，打造多學(xué)科交叉融合的科研平臺(tái)，綜合自由探索、醫(yī)學(xué)目標(biāo)導(dǎo)向、有組織科研等途徑，實(shí)踐新型科研模式和體制機(jī)制，培養(yǎng)適應(yīng)醫(yī)學(xué)科學(xué)創(chuàng)新發(fā)展的優(yōu)秀人才，逐步推進(jìn)醫(yī)教研產(chǎn)的深度融合，助力首都醫(yī)科大學(xué)成為世界一流的醫(yī)科大學(xué)。
實(shí)驗(yàn)室介紹
首都醫(yī)學(xué)科學(xué)創(chuàng)新中心免疫研究所孫少聰實(shí)驗(yàn)室長(zhǎng)期致力于T細(xì)胞的功能和機(jī)制研究。使用信號(hào)轉(zhuǎn)導(dǎo)、CRISPR基因篩選、單細(xì)胞RNA測(cè)序和基因敲除小鼠等多種方法研究T細(xì)胞激活、分化、效應(yīng)功能和耗竭的分子機(jī)理，從而鑒定關(guān)鍵性T細(xì)胞調(diào)節(jié)因子。近期工作還包括運(yùn)用生物信息學(xué)手段分析癌癥患者腫瘤測(cè)序數(shù)據(jù)庫(kù)，鑒定癌癥免疫調(diào)節(jié)因子，然后用小鼠模型進(jìn)行機(jī)理研究。自身免疫研究包括多發(fā)行硬化癥、SLE和腸炎的小鼠模型。孫教授團(tuán)隊(duì)在該領(lǐng)域已經(jīng)做出了許多影響深遠(yuǎn)的貢獻(xiàn)，包括發(fā)現(xiàn)多種調(diào)節(jié)T細(xì)胞功能和腫瘤免疫/自身免疫的關(guān)鍵因子。這些工作具有很好的轉(zhuǎn)化前景，對(duì)藥物開(kāi)發(fā)和疾病治療有重要指導(dǎo)作用。實(shí)驗(yàn)室也運(yùn)用癌癥免疫治療小鼠模型進(jìn)行轉(zhuǎn)化研究，探索免疫治療的改進(jìn)方法。
實(shí)驗(yàn)室近期代表性論文
Nature Cell Biology 24:1165-1176, 2022, PMID: 35773432
Nature Immunology 22:193-204, 2021, PMID: 33398181
Nature Cell Biology 21:1604-1614, 2019, PMID: 31792381
Nature Immunology 20:879-889, 2019, PMID: 31182807
Nature Immunology 19:1224-1235, 2018, PMID: 30250187
Nature 545:365-369, 2017, PMID: 28489822
Nature Immunology 17:259-268, 2016, PMID: 26808229
Nature Immunology 15:562-570, 2014, PMID: 24777531
Immunity 40:692-705, 2014, PMID: 24792914
Nature Medicine 19:595-602,2013, PMID: 23603814
Nature 494:371-374, 2013, PMID: 23334419
掃碼了解更多（請(qǐng)點(diǎn)擊鏈接查看詳情）
科研助理
一、崗位職責(zé)
1. RNA測(cè)序和單細(xì)胞多組學(xué)數(shù)據(jù)生物信息學(xué)分析；
2. 通過(guò)生信分析協(xié)助團(tuán)隊(duì)開(kāi)展課題研究；
3. 參與生信數(shù)據(jù)分析討論會(huì)。
二、任職要求
1. 具有生命科學(xué)或生物信息學(xué)本科及以上學(xué)歷；
2. 具有生物信息學(xué)分析相關(guān)專(zhuān)業(yè)背景；
3. 能夠熟練分析單細(xì)胞RNA測(cè)序數(shù)據(jù)和公共數(shù)據(jù)庫(kù)再分析；
4. 兼具生物信息學(xué)和生物醫(yī)學(xué)研究背景者優(yōu)先考慮。
福利待遇
1. 根據(jù)應(yīng)聘者的工作經(jīng)驗(yàn)和能力，提供具有市場(chǎng)競(jìng)爭(zhēng)力的薪酬（詳情面談）；
2. 享受五險(xiǎn)一金、帶薪年假、體檢和補(bǔ)充醫(yī)療保險(xiǎn)等；
3. 支持個(gè)人職業(yè)發(fā)展，提供必要的工作相關(guān)專(zhuān)業(yè)培訓(xùn)。
申請(qǐng)方法
有意者請(qǐng)將個(gè)人簡(jiǎn)歷及相關(guān)材料發(fā)送至招聘郵箱：ssun@cimrbj.ac.cn，請(qǐng)【點(diǎn)擊下方“立即投遞/投遞簡(jiǎn)歷”，即刻進(jìn)行職位報(bào)名】。郵件標(biāo)題請(qǐng)注明科研助理+應(yīng)聘者姓名。
聯(lián)系人：孫老師
聯(lián)系地址：北京市豐臺(tái)區(qū)右安門(mén)外西頭條10號(hào)-首都醫(yī)學(xué)科學(xué)創(chuàng)新中心
本招聘長(zhǎng)期有效，至招聘到合適人選為止。
ABOUT CIMR
Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn
Laboratory Introduction
A major focus of the lab is to study the molecular mechanisms that regulate T cell activation, differentiation, effector function, and exhaustion using a variety of cutting-edge techniques, such as signal transduction, CRISPR library screening, single-cell RNA sequencing, and knockout mouse models. Our recent work also includes the use of bioinformatics to analyze tumor sequencing databases of cancer patients, identify cancer immunomodulators, and then conduct mechanistic studies using mouse models. Autoimmune studies include mouse models of multiple sclerosis, SLE, and colitis. Professor Sun's team has made many significant contributions in this field, including the discovery of key factors regulating T cell functions in autoimmunity and cancer immunity. Our work also has strong translational potential and plays an important guiding role in drug development and disease treatment. The laboratory also uses mouse models of cancer immunotherapy to conduct translational studies and explore improved methods of immunotherapy.
Representative Publications:
Nature Cell Biology 24:1165-1176, 2022, PMID: 35773432
Nature Immunology 22:193-204, 2021, PMID: 33398181
Nature Cell Biology 21:1604-1614, 2019, PMID: 31792381
Nature Immunology 20:879-889, 2019, PMID: 31182807
Nature Immunology 19:1224-1235, 2018, PMID: 30250187
Nature 545:365-369, 2017, PMID: 28489822
Nature Immunology 17:259-268, 2016, PMID: 26808229
Nature Immunology 15:562-570, 2014, PMID: 24777531
Immunity 40:692-705, 2014, PMID: 24792914
Nature Medicine 19:595-602,2013, PMID: 23603814
Nature 494:371-374, 2013, PMID: 23334419
Scan to Learn More
Open Positions
Bioinformatic Research Assistant
Main Responsibilities
a. Carrying out bioinformatic analysis of RNA sequencing and single-cell multi-omics data.
b. Assisting research team in conducting research projects by providing bioinformatic analysis.
Qualifications
a. Possess a bachelor’s degree or higher in life sciences or bioinformatics.
b. With research background in bioinformatics or related fields.
c. With experience in bioinformatic analysis of single-cell RNA sequencing data or data mining of public datasets.
d. Candidates with both bioinformatic and biological research experiences are preferred.
Compensation and Benefits
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
How to apply
Please send resume and related application materials to ssun@cimrbj.ac.cn and indicate the applicant name and specific job position in the email subject.
Contact Person: Dr. Sun
This recruitment is valid for the long term until a suitable candidate is recruited.
信息來(lái)源于網(wǎng)絡(luò)，如有變更請(qǐng)以原發(fā)布者為準(zhǔn)。
來(lái)源鏈接：
https://mp.weixin.qq.com/s/Q8Z_czKJGMP9zb5kMEjS0A
