首都醫(yī)學(xué)科學(xué)創(chuàng)新中心[Chinese Institutes for Medical Research (CIMR), Beijing]（簡(jiǎn)稱創(chuàng)新中心）是北京市新成立的具有獨(dú)立法人資格的新型研發(fā)機(jī)構(gòu)。創(chuàng)新中心以推動(dòng)醫(yī)學(xué)科學(xué)發(fā)展、改善人類健康為目標(biāo)，開展生物醫(yī)學(xué)研究，致力于提升醫(yī)學(xué)科學(xué)創(chuàng)新與成果轉(zhuǎn)化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學(xué)家，與首都醫(yī)學(xué)教育和科學(xué)研究?jī)?yōu)質(zhì)資源緊密合作，打造多學(xué)科交叉融合的科研平臺(tái)，綜合自由探索、醫(yī)學(xué)目標(biāo)導(dǎo)向、有組織科研等途徑，實(shí)踐新型科研模式和體制機(jī)制，培養(yǎng)適應(yīng)醫(yī)學(xué)科學(xué)創(chuàng)新發(fā)展的優(yōu)秀人才，逐步推進(jìn)醫(yī)教研產(chǎn)的深度融合，助力首都醫(yī)科大學(xué)成為世界一流的醫(yī)科大學(xué)。
一、實(shí)驗(yàn)室介紹
尤忠勝教授分別在浙江大學(xué)，中科院上海生化所、美國(guó)加州大學(xué)圣地亞哥分校（University of California, San Diego）生物系取得學(xué)士、碩士、博士學(xué)位，在索爾克生物研究所（Salk Institute）進(jìn)行博士后研究。2009年成為美國(guó)圣路易斯華盛頓大學(xué)醫(yī)學(xué)院（Washington University in St. Louis, School of Medicine, WashU Medicine）細(xì)胞生物學(xué)與生理學(xué)系助理教授，2023年晉升為正教授。現(xiàn)擔(dān)任首都醫(yī)學(xué)科學(xué)創(chuàng)新中心資深研究員、腫瘤研究所副所長(zhǎng)，圣路易斯華盛頓大學(xué)客座教授。
尤忠勝實(shí)驗(yàn)室主要研究細(xì)胞基因組維持、RNA質(zhì)量監(jiān)測(cè)以及先天免疫機(jī)制，開發(fā)針對(duì)腫瘤、自身免疫等疾病的新型治療策略和藥物。在Nature Medicine、Molecular Cell、Nature Cell Biology等刊物發(fā)表多篇高水平論文，報(bào)道原創(chuàng)性發(fā)現(xiàn)。
本實(shí)驗(yàn)室為不同學(xué)術(shù)背景的研究者提供開放的平臺(tái)，誠(chéng)邀有志之士與我們共赴探索、創(chuàng)新之旅。尤忠勝教授具有豐富的學(xué)生和博后培養(yǎng)經(jīng)驗(yàn)，曾任WashU分子細(xì)胞博士生培養(yǎng)項(xiàng)目（MCB Graduate Program）聯(lián)合主任、生物與生物醫(yī)學(xué)部（Division of Biology and Biomedical Sciences）執(zhí)行委員會(huì)委員。
實(shí)驗(yàn)室研究方向
1. 基因組穩(wěn)定性、RNA質(zhì)量監(jiān)測(cè)缺陷與先天免疫系統(tǒng)的相互作用；
2. 離子和離子通道蛋白在cGAS/STING介導(dǎo)的先天免疫反應(yīng)中的調(diào)控作用；
3. 靶向TRPV2-STING互作，開發(fā)用于腫瘤與自身免疫疾病的精準(zhǔn)治療策略；
4. 剪接體突變相關(guān)腫瘤中的NMD通路失調(diào)與靶向治療前景。
近期主要研究成果
1. 全新基因組保護(hù)信號(hào)通路：發(fā)現(xiàn)并解析一條由胞質(zhì)DNA激活、Ca2?介導(dǎo)的復(fù)制叉保護(hù)通路，鑒定了 10 余個(gè)核心調(diào)控因子（Li et al., Mol Cell 2019; Li et al., Mol Cell 2023; Kong et al., Nat Commun 2024）；
2. TRPV2-STING互作: 首次發(fā)現(xiàn)STING與鈣離子通道蛋白TRPV2在內(nèi)質(zhì)網(wǎng)上的相互作用，該互作調(diào)控細(xì)胞內(nèi)鈣離子水平，并控制cGAS/STING先天免疫系統(tǒng)的靜息與激活（Li et al., Mol Cell 2023; Cheng et al., Cell Rep, 2026）；
3. 無(wú)義 RNA 降解調(diào)控與腫瘤治療：構(gòu)建多個(gè)NMD報(bào)告系統(tǒng)，用于高通量藥物篩選與全基因組CRISPR遺傳篩選，鑒定多個(gè)NMD抑制劑及調(diào)控因子；揭示NMD是攜帶剪接體突變的血液腫瘤的潛在治療靶點(diǎn) （Nickless et al., Nat Med 2014; Nickless et al., JBC 2017; Cheruiyot et al., Cancer Res 2021）。
代表性文章
Cell Reports, 2026, doi: 10.1016/j.celrep.2025.116745. PMID: 41411133.
Nature Communications, 2024, doi: 10.1038/s41467-024-48988-6. PMID: 38816425.
Molecular Cell, 2023, doi: 10.1016/j.molcel.2022.12.034. PMID: 36696898.
Molecular Cell, 2019, doi: 10.1016/j.molcel.2019.04.003. PMID: 31053472.
Cancer Research, 2021, doi: 10.1158/0008-5472.CAN-20-4016. PMID: 34215620.
Nature Medicine, 2014, doi: 10.1038/nm.3620. PMID: 25064126.
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二、招聘崗位
(一) 副研究員（1-2名）、助理研究員（1-2名）
主要職責(zé)
1. 在PI指導(dǎo)下獨(dú)立開展研究工作；
2. 協(xié)助PI指導(dǎo)研究生，撰寫研究論文和項(xiàng)目申請(qǐng)。
任職要求
1. 具有細(xì)胞生物學(xué)、生物信息學(xué)、結(jié)構(gòu)生物學(xué)或其他相關(guān)領(lǐng)域的研究背景，3年或以上博后經(jīng)歷；
2. 以第一作者身份在領(lǐng)域內(nèi)主流期刊上發(fā)表過(guò)研究論文；
3. 具備獨(dú)立開展科研工作和指導(dǎo)研究生能力；
4. 具有高漲的科研熱情、嚴(yán)謹(jǐn)?shù)目蒲袘B(tài)度、良好的溝通能力和團(tuán)隊(duì)合作精神；
5. 具備良好的英語(yǔ)讀寫和交流能力，能夠使用英文撰寫論文。
(二) 博士后（2-3名）
主要職責(zé)
1. 在PI指導(dǎo)下獨(dú)立開展研究工作；
2. 協(xié)助指導(dǎo)研究生以及撰寫論文和基金申請(qǐng)。
任職要求
1. 已獲得或即將獲得博士學(xué)位，具有細(xì)胞生物學(xué)、結(jié)構(gòu)生物學(xué)、生物信息學(xué)或其他相關(guān)領(lǐng)域的研究背景；
2. 以第一作者身份在領(lǐng)域內(nèi)主流期刊上發(fā)表過(guò)或即將發(fā)表研究論文；
3. 具備獨(dú)立開展科研工作能力；
4. 具有高漲的科研熱情、嚴(yán)謹(jǐn)?shù)目蒲袘B(tài)度、良好的溝通能力和團(tuán)隊(duì)合作精神；
5. 具備良好的英語(yǔ)讀寫和日常交流能力，能夠使用英文撰寫論文。
(三) 科研助理（1-2名）
主要職責(zé)
1. 獨(dú)立或協(xié)助團(tuán)隊(duì)開展課題研究；
2. 協(xié)助實(shí)驗(yàn)室運(yùn)行管理。
任職要求
1. 大學(xué)本科學(xué)歷及以上，分子生物學(xué)、細(xì)胞生物學(xué)、生物化學(xué)或其它相關(guān)專業(yè)；
2. 掌握分子生物學(xué)基本原理及操作能力，有細(xì)胞生物學(xué)、小鼠模型等研究經(jīng)歷優(yōu)先；
3. 誠(chéng)實(shí)嚴(yán)謹(jǐn)，具備良好的溝通能力和團(tuán)隊(duì)協(xié)作能力；
4. 具備良好的英語(yǔ)讀寫和日常交流能力。
三、福利待遇
1. 根據(jù)應(yīng)聘者的工作經(jīng)驗(yàn)和能力，提供具有市場(chǎng)競(jìng)爭(zhēng)力的薪酬（詳情面談）；
2. 享受五險(xiǎn)一金、帶薪年假、體檢和補(bǔ)充醫(yī)療保險(xiǎn)等；
3. 支持個(gè)人職業(yè)發(fā)展，提供必要的工作相關(guān)專業(yè)培訓(xùn)。
四、申請(qǐng)方法
應(yīng)聘者請(qǐng)將個(gè)人簡(jiǎn)歷、研究興趣或計(jì)劃、2-3名推薦人的姓名及聯(lián)系方式，以及其他能證明科研能力的相關(guān)電子文件發(fā)送到郵箱zyou@cimrbj.ac.cn，請(qǐng)【點(diǎn)擊下方“立即投遞/投遞簡(jiǎn)歷”，即刻進(jìn)行職位報(bào)名】，郵件主題請(qǐng)注明“應(yīng)聘者名字+具體應(yīng)聘職位”。
聯(lián)系人：尤忠勝
聯(lián)系地址：北京市豐臺(tái)區(qū)右安門外西頭條10號(hào)-首都醫(yī)學(xué)科學(xué)創(chuàng)新中心
本招聘長(zhǎng)期有效，至招聘到合適人選為止。
ABOUT CIMR
Chinese Institutes for
Medical Research (CIMR) is a newly founded institution dedicated to fundamental
and translational medical research. CIMR is located at the main campus of the
Laboratory Introduction
Dr. You is currently
an Investigator at CIMR and Associate Director of the Chinese Institute for
Cancer Research within CIMR. Prior to joining CIMR in 2025, he was a tenured
professor at
Major Research Projects:
The laboratory focuses on the following key research areas:
a. Intersection of DNA/RNA surveillance with innate immunity.
b. Emerging roles of ions and ion channels in regulating cGAS/STING innate immune signaling.
c. Therapeutic targeting of the TRPV2-STING axis in cancer and autoimmunity.
d. Exploiting NMD vulnerability in spliceosome-mutant cancers.
Major Contributions:
a. Discovered a novel cytosolic DNA-elicited, Ca2+-mediated signaling pathway that safeguards DNA replication forks to preserve genome stability (Mol Cell, 2019; Mol Cell, 2023; Nat Commun, 2024).
b. Uncovered a novel interplay on the endoplasmic reticulum between the ion channel TRPV2 and the innate immune sensor STING, revealing a new mechanism for the co-regulation of Ca2+ dynamics and immune activation (Mol Cell, 2023; Cell Rep, 2026).
c. Pioneered the development of NMD reporter systems, enabling the identification of novel NMD inhibitors and genetic regulators, and demonstrated that NMD is modulated by intracellular Ca2+ and persistent DNA damage (Nat Med, 2014; JBC, 2017).
d. Established NMD as a promising therapeutic target for cancers harboring spliceosome mutations (Cancer Res, 2021, Cancer Res, in review).
Representative Publications
Cell Reports, 2026, doi: 10.1016/j.celrep.2025.116745. PMID: 41411133.
Nature Communications, 2024, doi: 10.1038/s41467-024-48988-6. PMID: 38816425.
Molecular Cell, 2023, doi: 10.1016/j.molcel.2022.12.034. PMID: 36696898.
Molecular Cell, 2019, doi: 10.1016/j.molcel.2019.04.003. PMID: 31053472.
Cancer Research, 2021, doi: 10.1158/0008-5472.CAN-20-4016. PMID: 34215620.
Nature Medicine, 2014, doi: 10.1038/nm.3620. PMID: 25064126.
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Open Positions
Research Associate Investigator/
Research Assistant Investigator
Main Responsibilities
a. Conduct research independently under the guidance of the PI.
b. Assist in supervising graduate students and in writing research papers and grant proposals.
Qualifications
a. A PhD in cell biology, bioinformatics, structural biology or related fields, with at least 3 years of postdoctoral research experience.
b. A strong publication record, evidenced by first-author publications in reputable journals.
c. Demonstrated ability to conduct independent research and mentor graduate students, with a strong passion for scientific research.
d. High proficiency in written and spoken English, with the ability to communicate effectively and prepare manuscripts.
Postdoctoral Researcher
Main Responsibilities
a. Conduct research projects independently under the guidance of the PI
b. Assist in supervising graduate students and writing research papers and grant proposals.
Qualifications
a. A recent PhD in cell biology, bioinformatics, structural biology or related fields
b. Proven track record of first-author publications in reputable journals in the field.
c. Demonstrated ability to conduct independent research and mentor graduate students, with a strong passion for scientific research.
d. Proficiency in written and spoken English, with the ability to communicate effectively and prepare manuscripts.
Research Assistant
Main Responsibilities
a. Assist the team in conducting research projects.
b. Oversee the daily operation and maintenance of laboratory equipment, and assist the PI with lab management and administrative tasks.
Qualifications
a. Bachelor's degree or higher in molecular biology, cell biology, biochemistry or related disciplines.
b. Proactive work attitude with strong organizational skills and attention to detail.
c. Excellent communication skills and a collaborative team spirit.
d. Proficiency in English reading, writing, and daily communication.
Welfare Treatment
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
How to apply
To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zyou@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.
Contact person: Zhongsheng You, PhD
This recruitment is valid for the long term until a suitable candidate is recruited.
信息來(lái)源于網(wǎng)絡(luò)，如有變更請(qǐng)以原發(fā)布者為準(zhǔn)。
來(lái)源鏈接：
https://mp.weixin.qq.com/s/hAcSguphbGX7zDr9mSUT
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