首都醫(yī)學科學創(chuàng)新中心免疫研究所孫少聰實驗室招聘博士后或副研究員以開展癌癥免疫和自身免疫的基礎和轉(zhuǎn)化研究。本實驗室長期致力于T細胞的功能和機制研究。使用信號轉(zhuǎn)導，CRISPR基因篩選，單細胞RNA測序，和基因敲除小鼠等多種方法研究T細胞激活，分化，效應功能和耗竭的分子機理，從而鑒定關鍵性T細胞調(diào)節(jié)因子。近期工作還包括運用生物信息學手段分析癌癥患者腫瘤測序數(shù)據(jù)庫，鑒定癌癥免疫調(diào)節(jié)因子，然后用小鼠模型進行機理研究。自身免疫研究包括多發(fā)行硬化癥，SLE，和腸炎的小鼠模型。孫教授團隊在該領域已經(jīng)做出了許多影響深遠的貢獻，包括發(fā)現(xiàn)多種調(diào)節(jié)T細胞功能和腫瘤免疫/自身免疫的關鍵因子。這些工作具有很好的轉(zhuǎn)化前景，對藥物開發(fā)和疾病治療有重要指導作用。實驗室也運用癌癥免疫治療小鼠模型進行轉(zhuǎn)化研究，探索免疫治療的改進方法。

實驗室近期代表性論文有：

Nature Cell Biology 24:1165-1176, 2022, PMID: 35773432

Nature Immunology 22:193-204, 2021, PMID: 33398181

Nature Cell Biology 21:1604-1614, 2019, PMID: 31792381

Nature Immunology 20:879-889, 2019, PMID: 31182807

Nature Immunology 19:1224-1235, 2018, PMID:30250187

Nature 545:365-369, 2017, PMID: 28489822

Nature Immunology 17:259-268, 2016, PMID:26808229

Nature Immunology 15:562-570, 2014, PMID: 24777531

Immunity 40:692-705, 2014, PMID:24792914

Nature Medicine 19:595-602,2013, PMID: 23603814

Nature 494:371-374, 2013, PMID: 23334419

崗位職責：

1.RNA測序和單細胞多組學數(shù)據(jù)生物信息學分析

2.通過生信分析協(xié)助團隊開展課題研究

3.參與生信數(shù)據(jù)分析討論會

應聘要求：

1.具有生命科學或生物信息學本科及以上學歷；

2.具有生物信息學分析相關專業(yè)背景；

3.能夠熟練分析單細胞RNA測序數(shù)據(jù)和公共數(shù)據(jù)庫再分析；

4.兼具生物信息學和生物醫(yī)學研究背景者優(yōu)先考慮。

1.根據(jù)應聘者的工作經(jīng)驗和能力提供具有市場競爭力的薪酬 （詳情面談）;

2.享受五險一金、帶薪年假，體檢和補充醫(yī)療保險等;

3.支持個人職業(yè)發(fā)展，提供必要的工作相關專業(yè)培訓。

請將申請材料發(fā)送至郵箱ssun@cimrbj.ac.cn。（郵件標題注明：應聘某某崗位+本人姓名+高校人才網(wǎng)）【快捷投遞：點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】

聯(lián)系人：孫老師

The laboratory of Shao-Cong Sun at the Chinese Institutes for Medical Research (CIMR) is recruiting motivated Postdoctoral Fellows and Research Associate Investigators to conduct basic and translational research in Cancer Immunology and Autoimmunity. A major focus of the lab is to study the molecular mechanisms that regulate T cell activation, differentiation, effector function, and exhaustion using a variety of cutting-edge techniques, such as signal transduction, CRISPR library screening, single-cell RNA sequencing, and knockout mouse models. Our recent work also includes the use of bioinformatics to analyze tumor sequencing databases of cancer patients, identify cancer immunomodulators, and then conduct mechanistic studies using mouse models. Autoimmune studies include mouse models of multiple sclerosis, SLE, and colitis. Professor Sun's team has made many significant contributions in this field, including the discovery of key factors regulating T cell functions in autoimmunity and cancer immunity. Our work also has strong translational potential and plays an important guiding role in drug development and disease treatment. The laboratory also uses mouse models of cancer immunotherapy to conduct translational studies and explore improved methods of immunotherapy.

1.Carrying out bioinformatic analysis of RNA sequencing and single-cell multi-omics data

2.Assisting research team in conducting research projects by providing bioinformatic analysis

1.Possess a bachelor’s degree or higher in life sciences or bioinformatics

2.With research background in bioinformatics or related fields

3.With experience in bioinformatic analysis of single-cell RNA sequencing data or data mining of public datasets

4.Candidates with both bioinformatic and biological research experiences are preferred

1.Provide competitive salary based on the applicant’s work experience and ability (salary negotiable);

2.Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave;

3.Support career development and provide relevant professional guidance.

Please send resume and related application materials to ssun@cimrbj.ac.cn and indicate the applicant name and specific job position in the email subject.