上海交通大學(xué)醫(yī)學(xué)院附屬瑞金醫(yī)院前沿治療研究中心現(xiàn)招聘博士后研究人員。本中心由首席科學(xué)家Michael Shepard教授領(lǐng)銜，依托瑞金醫(yī)院豐富的臨床資源和雄厚的科研實(shí)力，聚焦腫瘤、炎癥與自身免疫性疾病的前沿治療研究，致力于推動(dòng)治療模式的創(chuàng)新。我們擁有多學(xué)科專家團(tuán)隊(duì)、國(guó)際一流的研究設(shè)施與實(shí)驗(yàn)平臺(tái)，為高水平科學(xué)研究提供堅(jiān)實(shí)基礎(chǔ)。
Michael Shepard教授簡(jiǎn)介
Michael Shepard教授是國(guó)際公認(rèn)的生物技術(shù)創(chuàng)新者和癌癥研究先驅(qū)。作為前沿治療研究中心首席科學(xué)家兼腫瘤生物學(xué)顧問(wèn)，他開創(chuàng)了多個(gè)革命性療法：作為赫賽?。ㄇ字閱慰梗┑暮诵陌l(fā)明人之一，其研發(fā)的HER2陽(yáng)性乳腺癌療法已惠及全球逾50萬(wàn)患者；他率先提出"泛HER"抑制概念、酶催化治療技術(shù)（ECTA），并將首個(gè)腺病毒基因療法推進(jìn)至臨床試驗(yàn)階段，促成近期獲批用于高危膀胱癌的非復(fù)制型腺病毒基因療法Adstiladrin。目前，他正將成功的癌癥治療模式拓展至炎癥與自身免疫性疾病領(lǐng)域。其卓越貢獻(xiàn)榮獲2019年拉斯克-迪貝基臨床醫(yī)學(xué)研究獎(jiǎng)、2007年沃倫?阿爾珀特獎(jiǎng)等國(guó)際殊榮。Shepard教授擁有50余項(xiàng)生物治療與診斷專利，多次在權(quán)威期刊發(fā)表論著，并積極通過(guò)學(xué)術(shù)講座與合作項(xiàng)目培育青年科學(xué)家。他現(xiàn)任瑞金醫(yī)院、達(dá)蒙?魯尼恩癌癥研究基金會(huì)及俄勒岡健康科學(xué)大學(xué)騎士研究所特邀專家，在科研與教育領(lǐng)域持續(xù)發(fā)揮引領(lǐng)作用。
博士后研究項(xiàng)目：
本項(xiàng)目致力于開發(fā)針對(duì)急性髓系白血病（AML）的新型多特異性抗體，旨在通過(guò)靶向抑制更廣泛的AML細(xì)胞群體，且具有特異性增強(qiáng)的下一代抗體，以突破當(dāng)前AML治療的局限。入選的博士后將參與設(shè)計(jì)，研發(fā)、功能驗(yàn)證等創(chuàng)新研究。
核心職責(zé)：
? 設(shè)計(jì)、構(gòu)建、表達(dá)新型多特異性抗體
? 采用多種純化技術(shù)（親和、離子交換、分子篩等）進(jìn)行抗體純化與優(yōu)化
? 通過(guò)生化與生物物理方法（SDS-PAGE、SEC-HPLC、BLI/SPR親和力測(cè)定）檢測(cè)抗體純度與特性
? 利用多種細(xì)胞（AML細(xì)胞、效應(yīng)細(xì)胞等）和多種平臺(tái)技術(shù)（流式細(xì)胞術(shù)、ELISA）對(duì)多特異抗體展開功能及細(xì)胞毒性評(píng)估
? 分析實(shí)驗(yàn)數(shù)據(jù)、完善研究記錄，并定期在實(shí)驗(yàn)室會(huì)議與學(xué)術(shù)會(huì)議上匯報(bào)成果
? 撰寫優(yōu)質(zhì)學(xué)術(shù)論文
任職要求：
? 近期或即將獲得生物化學(xué)、分子生物學(xué)、免疫學(xué)、生物工程等相
? 具備分子生物學(xué)技術(shù)實(shí)戰(zhàn)經(jīng)驗(yàn)（PCR、克隆、質(zhì)粒設(shè)計(jì)與制備）
? 擁有蛋白質(zhì)表達(dá)與純化（?KTA SEC-FPLC）的經(jīng)驗(yàn)
? 熟練掌握細(xì)胞實(shí)驗(yàn)技術(shù)（細(xì)胞培養(yǎng)、轉(zhuǎn)染、流式細(xì)胞術(shù)、功能實(shí)驗(yàn)）
? 以第一作者在同行評(píng)審期刊發(fā)表過(guò)多篇論文
? 具有獨(dú)立科研與解決問(wèn)題能力
? 團(tuán)隊(duì)協(xié)作能力
? 中英文雙語(yǔ)工作能力（書面與口語(yǔ)）
我們提供：
? 具有競(jìng)爭(zhēng)力的薪酬與完善福利待遇（根據(jù)資歷核定）
? 對(duì)博士后的職業(yè)發(fā)展提供幫助
? 尖端核心設(shè)施支持（流式細(xì)胞儀、共聚焦顯微鏡、Biacore、AKTA、動(dòng)物模型與臨床樣本平臺(tái)）
? 跨學(xué)科、支持性、動(dòng)態(tài)化的科研環(huán)境
? 學(xué)術(shù)交流與會(huì)議參會(huì)機(jī)會(huì)
申請(qǐng)方式：
請(qǐng)將以下材料合并為PDF文件發(fā)送至郵箱地址：juan2025SH@outlook.com，ruijinboshihou@163.com，郵件主題注明"博士后申請(qǐng)+高校人才網(wǎng)"：【快捷投遞：點(diǎn)擊下方“立即投遞/投遞簡(jiǎn)歷”，即刻進(jìn)行職位報(bào)名】
1. Cover Letter：闡述研究方向、職業(yè)規(guī)劃及崗位適配性
2. 詳細(xì)簡(jiǎn)歷（含出版物列表）
3. 三位推薦人的聯(lián)系方式
Job Announcement: Postdoctoral Fellow – Multispecific Antibody Therapeutics
Introduction of Research Platform
The Frontiers in
Introduction of Professor Michael Shepard
Professor Michael Shepard is a globally
recognized innovator in biotechnology and a pioneering figure in cancer
research. As the Chief Scientist of the Frontiers in
Post-doctoral Project Description:
We are seeking a highly motivated and creative Postdoctoral Fellow to join an innovative research project focused on developing novel multi-specific antibodies for Acute Myeloid Leukemia (AML). This project aims to overcome current limitations in immunotherapy by engineering next-generation antibodies capable of targeting broader AML cell populations with enhanced selectivity. The successful candidate will have the unique opportunity to drive this project from initial computational design through in vitro characterization and preclinical validation.
Key Responsibilities:
? Design, construct, and express novel multispecific antibodies using mammalian expression systems (e.g., HEK293, CHO cells)
? Optimize and perform antibody purification using various chromatographic techniques (affinity, ion-exchange, size-exclusion)
? Characterize antibody properties using biochemical and biophysical methods (SDS-PAGE, SEC-HPLC, BLI/SPR for affinity measurements)
? Evaluate antibody functionality through comprehensive in vitro assays including binding assessments (flow cytometry, ELISA) and cytotoxicity studies using primary AML cells and effector cells
? Analyze experimental data, maintain detailed documentation, and present findings at lab meetings and scientific conferences
? Prepare manuscripts for publication in high-impact journals
Required Qualifications:
? Recently awarded or upcoming Ph.D. in Biochemistry, Molecular Biology, Immunology, Bioengineering, or related field
? Extensive hands-on experience with molecular biology techniques (PCR, cloning, plasmid design and preparation)
? Demonstrated expertise in protein expression (transient/stable transfection) and purification (?KTA FPLC systems)
? Proficiency with cell-based assays (cell culture, transfection, flow cytometry, functional assays)
? Strong publication record with first-author papers in peer-reviewed journals
? Excellent problem-solving abilities and capacity for independent research
? Ability to work effectively in a collaborative team environment
? Fluency in both English and Chinese (written and verbal)
We Offer:
? Competitive salary and comprehensive benefits package commensurate with experience
? Dedicated mentorship focused on career development in academia or industry
? Access to state-of-the-art core facilities (flow cytometry, microscopy, Biacore, AKTA, animal models, and clinical samples)
? Dynamic, supportive, and interdisciplinary research environment
? Opportunities for professional networking and conference travel
Application Process:
Please submit the following materials as a single PDF file to Email Address：juan2025SH@outlook.com，ruijinboshihou@163.com with the subject line "Postdoc Application: Cover letter outlining research interests, career goals, and specific qualifications for this position
1.Current CV including publication list
2.Contact information for three professional references
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